Well, you will first need to actually design and code the design you want for your myspace site. If you just want a new design and not use any of the elements such as friends, comments, etc. on the main page, then you can just use an overlay method to cover up everything else. It starts getting hard when you try and keep elements such as comments and friends while changing the layout and appearance of your page and then attempting to get it to work in the main browsers.