I Voted for (X)HTML Layout in CSS without tables. I've seen a lot of sites which weren't produced by photoshop, fireworks, flash or any other image creating/editing program that were really beautiful. Tables can be beautiful, but I remember when I was using those tableswith an ugly border, and how hard it was to force them to do what you want them to do. CSS looks more professional, is easier to edit and work with, and is being used more and more.