Start with the domain, the file-name of your page and it's title. Weight your keywords well - too many may be considered spam, too few and the term loses relevance.
Separate your content from your layout. Use header tags appropriately. If you use images directly in the page be sure to name them accordingly and to add appropriate alt and title tags.
Target key phrases rather than key words for a better chance of success.
Check that people are searching for your given words/phrases... It's all well and good being number one for "qualidigistical funknoramic designifications" (which I can guarantee you first place for with no effort
) but if nobody is searching for this then it's not that useful.